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No accumulation of methylphenidate is expected following multiple once daily oral dosing with Ritalin LA, however, there is a slight upward trend in the methylphenidate area under the curve (AUC) and peak plasma concentrations (Cmax1 and Cmax2) after oral administration of Ritalin LA 20 mg and 40 mg capsules to adults. Pharmacology, adverse reactions, warnings, and RITALIN LAside effects.
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